biostudies-literatureKusewitt DFNCI NIH HHSNational Institutes of HealthNIGMS NIH HHS106607https://www.ebi.ac.uk/biostudies/studies/S-EPMC11444091biostudies-literatureUnknown244Long-term administration of exogenous estrogen is known to cause urinary retention and marked, often fatal, bladder distention in both male and female mice. Estrogen-treated mice have increased bladder pressure and decreased urine flow, suggesting that urinary retention in estrogen-treated mice is due to infravesicular obstruction to urine outflow. Thus, the condition is commonly referred to as bladder outlet obstruction (BOO). Obesity can also lead to urinary retention. As the effects of estrogen are mediated by multiple receptors, including estrogen receptors ERα and ERβ and the G protein-coupled estrogen receptor (GPER), we sought to determine whether GPER plays a role in estrogen-induced BOO, particularly in the context of obesity. Wild type and GPER knockout (KO) mice fed a high-fat dThe Journal of steroid biochemistry and molecular biologyGPER expression prevents estrogen-induced urinary retention in obese mice.PMC11444091P30 CA016058R01 CA194496P20 GM121176K12 GM088021R01 CA163890P30 CA118100Woods CDProssnitz ERRosas ESharma GHathaway HJKusewitt DFfalseGPER expression prevents estrogen-induced urinary retention in obese mice.Long-term administration of exogenous estrogen is known to cause urinary retention and marked, often fatal, bladder distention in both male and female mice. Estrogen-treated mice have increased bladder pressure and decreased urine flow, suggesting that urinary retention in estrogen-treated mice is due to infravesicular obstruction to urine outflow. Thus, the condition is commonly referred to as bladder outlet obstruction (BOO). Obesity can also lead to urinary retention. As the effects of estrogen are mediated by multiple receptors, including estrogen receptors ERα and ERβ and the G protein-coupled estrogen receptor (GPER), we sought to determine whether GPER plays a role in estrogen-induced BOO, particularly in the context of obesity. Wild type and GPER knockout (KO) mice fed a high-fat d2024-01-01T00:00:00Z2024 Nov2026-06-05T07:32:28.758Z2026-05-14T03:12:55.231ZS-EPMC114440913919753910.1016/j.jsbmb.2024.106607