{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walter J"],"funding":["University of Zurich"],"pagination":["gaae033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11444741"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(9)"],"pubmed_abstract":["Assisted reproductive technologies are an emerging field in equine reproduction, with species-dependent peculiarities, such as the low success rate of conventional IVF. Here, the 'cumulome' was related to the developmental capacity of its corresponding oocyte. Cumulus-oocyte complexes collected from slaughterhouse ovaries were individually matured, fertilized by ICSI, and cultured. After maturation, the cumulus was collected for proteomics analysis using label-free mass spectrometry (MS)-based protein profiling by nano-HPLC MS/MS and metabolomics analysis by UPLC-nanoESI MS. Overall, a total of 1671 proteins and 612 metabolites were included in the quantifiable 'cumulome'. According to the development of the corresponding oocytes, three groups were compared with each other: not matured (NM"],"journal":["Molecular human reproduction"],"pubmed_title":["Maturational competence of equine oocytes is associated with alterations in their 'cumulome'."],"pmcid":["PMC11444741"],"funding_grant_id":["FK-13-062"],"pubmed_authors":["Naegeli H","Galli C","Walter J","Colleoni S","Laczko E","Bleul U","Lazzari G","Fortes C","Roschitzki B","Grossmann J"],"additional_accession":[]},"is_claimable":false,"name":"Maturational competence of equine oocytes is associated with alterations in their 'cumulome'.","description":"Assisted reproductive technologies are an emerging field in equine reproduction, with species-dependent peculiarities, such as the low success rate of conventional IVF. Here, the 'cumulome' was related to the developmental capacity of its corresponding oocyte. Cumulus-oocyte complexes collected from slaughterhouse ovaries were individually matured, fertilized by ICSI, and cultured. After maturation, the cumulus was collected for proteomics analysis using label-free mass spectrometry (MS)-based protein profiling by nano-HPLC MS/MS and metabolomics analysis by UPLC-nanoESI MS. Overall, a total of 1671 proteins and 612 metabolites were included in the quantifiable 'cumulome'. According to the development of the corresponding oocytes, three groups were compared with each other: not matured (NM","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-06-06T03:22:21.016Z","creation":"2025-04-07T07:29:24.643Z"},"accession":"S-EPMC11444741","cross_references":{"pubmed":["39288330"],"doi":["10.1093/molehr/gaae033"]}}