biostudies-literatureUnknown43(4)Masamura YKeio University in the JST Global Science Campus ProgramLife Science Database Integration Project and the National Bioscience Database Center of the Japan Science and Technology AgencyDepression is a prevalent mental health disorder, and its incidence has increased further because of the coronavirus disease 2019 (COVID-19) pandemic. The gut microbiome has been suggested as a potential target for mental health treatment because of the bidirectional communication system between the brain and gastrointestinal tract, known as the gut-brain axis. We aimed to investigate the relationship between the human gut microbiome and depression screening by analyzing the abundance and types of microbiomes among individuals living in Japan, where mental health awareness and support may differ from those in other countries owing to cultural factors. We used a data-driven approach to evaluate the gut microbiome of participants who underwent commercial gut microbiota testing services and cBioscience of microbiota, food and health336-341https://www.ebi.ac.uk/biostudies/studies/S-EPMC11444865biostudies-literatureDifferences in the human gut microbiota with varying depressive symptom severity scores.PMC11444865Watanabe SKubo ROhta TMaekawa SMidorikawa YShinozaki NOMasamura YTakeda AKfalseDifferences in the human gut microbiota with varying depressive symptom severity scores.Depression is a prevalent mental health disorder, and its incidence has increased further because of the coronavirus disease 2019 (COVID-19) pandemic. The gut microbiome has been suggested as a potential target for mental health treatment because of the bidirectional communication system between the brain and gastrointestinal tract, known as the gut-brain axis. We aimed to investigate the relationship between the human gut microbiome and depression screening by analyzing the abundance and types of microbiomes among individuals living in Japan, where mental health awareness and support may differ from those in other countries owing to cultural factors. We used a data-driven approach to evaluate the gut microbiome of participants who underwent commercial gut microbiota testing services and c2024-01-01T00:00:00Z20242026-06-06T22:19:52.201Z2025-04-06T13:23:14.716ZS-EPMC114448653936412510.12938/bmfh.2023-049