{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Baidya Kayal E"],"pubmed_abstract":["Objective was to assess the precision and reproducibility of spatial penalty-based intravoxel incoherent motion (IVIM) methods in comparison to the conventional bi-exponential (BE) model-based IVIM methods. IVIM-MRI (11 b-values; 0-800 s/mm<sup>2</sup>) of forty patients (N = 40; Age = 17.7 ± 5.9 years; Male:Female = 30:10) with biopsy-proven osteosarcoma were acquired on a 1.5 Tesla scanner at 3 time-points: (i) baseline, (ii) after 1-cycle and (iii) after 3-cycles of neoadjuvant chemotherapy. Diffusion coefficient (D), Perfusion coefficient (D*) and Perfusion fraction (f) were estimated at three time-points in whole tumor and healthy muscle tissue using five methodologies (1) BE with three-parameter-fitting (BE), (2) Segmented-BE with two-parameter-fitting (BESeg-2), (3) Segmented-BE wit"],"journal":["Scientific reports"],"pagination":["22811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11445472"],"repository":["biostudies-literature"],"pubmed_title":["Reproducibility of spatial penalty-based methodologies for intravoxel incoherent motion analysis with diffusion MRI."],"pmcid":["PMC11445472"],"pubmed_authors":["Mehndiratta A","Ganguly S","Baidya Kayal E","Khare K","Sharma R","Bakhshi S","Kandasamy D"],"additional_accession":[]},"is_claimable":false,"name":"Reproducibility of spatial penalty-based methodologies for intravoxel incoherent motion analysis with diffusion MRI.","description":"Objective was to assess the precision and reproducibility of spatial penalty-based intravoxel incoherent motion (IVIM) methods in comparison to the conventional bi-exponential (BE) model-based IVIM methods. IVIM-MRI (11 b-values; 0-800 s/mm<sup>2</sup>) of forty patients (N = 40; Age = 17.7 ± 5.9 years; Male:Female = 30:10) with biopsy-proven osteosarcoma were acquired on a 1.5 Tesla scanner at 3 time-points: (i) baseline, (ii) after 1-cycle and (iii) after 3-cycles of neoadjuvant chemotherapy. Diffusion coefficient (D), Perfusion coefficient (D*) and Perfusion fraction (f) were estimated at three time-points in whole tumor and healthy muscle tissue using five methodologies (1) BE with three-parameter-fitting (BE), (2) Segmented-BE with two-parameter-fitting (BESeg-2), (3) Segmented-BE wit","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-26T08:51:40.61Z","creation":"2025-04-06T12:53:39.522Z"},"accession":"S-EPMC11445472","cross_references":{"pubmed":["39354013"],"doi":["10.1038/s41598-024-71173-0"]}}