biostudies-literatureFu LShandong Peninsula Engineering Research Center of Comprehensive Brine UtilizationResearch Initiation Fund of Binzhou Medical UniversityNational Natural Science Foundation of ChinaTaishan Scholar Project Special Funding595https://www.ebi.ac.uk/biostudies/studies/S-EPMC11446090biostudies-literatureUnknown22(1)<h4>Background</h4>Therapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective guiding strategies.<h4>Results</h4>Herein, we have developed a nanoplatforms Cy-NMNO@SiO₂ based on mesoporous silica materials loaded NIR-activatable small-molecule fluorescent probe Cy-NMNO for the synergistic treatment of photodynamic therapy/gas therapy (PDT/GT) in antibacterial and skin cancer. The theoretical calculation results showed that the low dissociation of N-NO in Cy-NMNO enabled it to dissociate effectively under NIR light irradiation, which is conducive to produce Cy and NO. Cy showed better ¹O₂ generation performance Journal of nanobiotechnologyNIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy.PMC1144609022007005ts20190962218040102018LS014BY2019KYQD39BY2020KYQD0150012304601Shan XHuang YYu SChen LFu LWang XSun XfalseNIR-activatable nitric oxide generator based on nanoparticles loaded small-molecule photosensitizers for synergetic photodynamic/gas therapy.<h4>Background</h4>Therapeutic approaches that combine conventional photodynamic therapy (PDT) with gas therapy (GT) to sensitize PDT are an attractive strategy, but the molecular structure design of the complex lacks effective guiding strategies.<h4>Results</h4>Herein, we have developed a nanoplatforms Cy-NMNO@SiO₂ based on mesoporous silica materials loaded NIR-activatable small-molecule fluorescent probe Cy-NMNO for the synergistic treatment of photodynamic therapy/gas therapy (PDT/GT) in antibacterial and skin cancer. The theoretical calculation results showed that the low dissociation of N-NO in Cy-NMNO enabled it to dissociate effectively under NIR light irradiation, which is conducive to produce Cy and NO. Cy showed better ¹O₂ generation performance 2024-01-01T00:00:00Z2024 Oct2025-04-03T23:48:55.835Z2025-04-03T23:48:55.835ZS-EPMC114460903935447610.1186/s12951-024-02878-7