{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu Y"],"funding":["NIDDK NIH HHS","Wellcome Trust"],"pagination":["243-250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11446830"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["634(8032)"],"pubmed_abstract":["Human mutations in neuropeptide Y (NPY) have been linked to high body mass index but not altered dietary patterns<sup>1</sup>. Here we uncover the mechanism by which NPY in sympathetic neurons<sup>2,3</sup> protects from obesity. Imaging of cleared mouse brown and white adipose tissue (BAT and WAT, respectively) established that NPY<sup>+</sup> sympathetic axons are a smaller subset that mostly maps to the perivasculature; analysis of single-cell RNA sequencing datasets identified mural cells as the main NPY-responsive cells in adipose tissues. We show that NPY sustains the proliferation of mural cells, which are a source of thermogenic adipocytes in both BAT and WAT<sup>4-6</sup>. We found that diet-induced obesity leads to neuropathy of NPY<sup>+</sup> axons and concomitant depletion of "],"journal":["Nature"],"pubmed_title":["Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat."],"pmcid":["PMC11446830"],"funding_grant_id":["UM1 DK105554"],"pubmed_authors":["Yao L","Zhou L","Gallo-Ferraz AL","Sarker G","Ciccarelli A","Martinez-Sanchez N","Velloso LA","Zhu Y","Chen J","Zhan C","Dustin ML","Abe I","Lee C","Domingos AI","Bombassaro B","Sidarta-Oliveira D","Kajimura S","Simoes MR","Horvath TL"],"additional_accession":[]},"is_claimable":false,"name":"Sympathetic neuropeptide Y protects from obesity by sustaining thermogenic fat.","description":"Human mutations in neuropeptide Y (NPY) have been linked to high body mass index but not altered dietary patterns<sup>1</sup>. Here we uncover the mechanism by which NPY in sympathetic neurons<sup>2,3</sup> protects from obesity. Imaging of cleared mouse brown and white adipose tissue (BAT and WAT, respectively) established that NPY<sup>+</sup> sympathetic axons are a smaller subset that mostly maps to the perivasculature; analysis of single-cell RNA sequencing datasets identified mural cells as the main NPY-responsive cells in adipose tissues. We show that NPY sustains the proliferation of mural cells, which are a source of thermogenic adipocytes in both BAT and WAT<sup>4-6</sup>. We found that diet-induced obesity leads to neuropathy of NPY<sup>+</sup> axons and concomitant depletion of ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T01:54:28.857Z","creation":"2025-04-04T01:54:28.857Z"},"accession":"S-EPMC11446830","cross_references":{"pubmed":["39198648"],"doi":["10.1038/s41586-024-07863-6"]}}