biostudies-literatureWang X-Ythe Natural Science Foundation of Inner Mongolia Autonomous Region of ChinaMOST | National Natural Science Foundation of China (NSFC)Inner Mongolia Engineering Technology Research Center of Germplasm Resources Conservation and UtilizationStudent Innovation and Entrepreneurship Training Programs of Inner Mongolia UniversityProgram for Young Talents of Science and technology in Universities of Inner Mongolia Autonouous Region of ChinaScience and Technology Leading Talent Team in Inner Mongolia Autonomous Region of ChinaMOST | National Natural Science Foundation of ChinaFirst-class scientific research projects of the Department of Education of Inner Mongolia Autonomous Region of Chinae0402523https://www.ebi.ac.uk/biostudies/studies/S-EPMC11448249biostudies-literatureUnknown12(10)The gut microbiota, a pivotal component of the intestinal mucosal barrier, is critical for host resistance to enteric pathogen infection. Here, we report a novel function of the potentially probiotic <i>Lactococcus garvieae</i> strain LG1 (<i>L. garvieae</i> strain LG1) in maintaining intestinal mucosal barrier integrity and protecting against foodborne <i>Clostridium perfringens</i> (<i>C. perfringens</i>) infection. <i>L. garvieae</i> was isolated from the intestinal contents of Chinese Mongolian sheep (MS) and exhibited potential probiotic properties. In a <i>C. perfringens</i> enterocolitis model, <i>L. garvieae-</i>pretreated mice were less susceptible to <i>C. perfringens</i> infection compared with Phosphate buffered solution (PBS)<i>-</i>pretreated mice, which manifested as higher Microbiology spectrumGut <i>Lactococcus garvieae</i> promotes protective immunity to foodborne <i>Clostridium perfringens</i> infection.PMC11448249No. 21400-222526No. YLXKZX-ND-031No. 32302886No. 32160832No. NJYT22104No. 2021BS03003No. 2022LJRC0009No. 21400-23269204, No. 11600-242603032024Zhang M-YMeng F-HMa Z-GWang X-YYu S-XLou Y-NChu Y-FLi F-XMa KLi J-QLei Y-XfalseGut <i>Lactococcus garvieae</i> promotes protective immunity to foodborne <i>Clostridium perfringens</i> infection.The gut microbiota, a pivotal component of the intestinal mucosal barrier, is critical for host resistance to enteric pathogen infection. Here, we report a novel function of the potentially probiotic <i>Lactococcus garvieae</i> strain LG1 (<i>L. garvieae</i> strain LG1) in maintaining intestinal mucosal barrier integrity and protecting against foodborne <i>Clostridium perfringens</i> (<i>C. perfringens</i>) infection. <i>L. garvieae</i> was isolated from the intestinal contents of Chinese Mongolian sheep (MS) and exhibited potential probiotic properties. In a <i>C. perfringens</i> enterocolitis model, <i>L. garvieae-</i>pretreated mice were less susceptible to <i>C. perfringens</i> infection compared with Phosphate buffered solution (PBS)<i>-</i>pretreated mice, which manifested as higher 2024-01-01T00:00:00Z2024 Oct2026-06-13T05:45:13.591Z2025-04-04T01:17:48.669ZS-EPMC114482493919063410.1128/spectrum.04025-23