biostudies-literatureDiz-de Almeida SEstrella de Levante S.A.Xunta de GaliciaInstituto de Salud Carlos IIIBanco SantanderAgencia Estatal de InvestigaciónCabildo Insular de TenerifeAxencia GAINFundación Canaria Instituto de Investigación Sanitaria de CanariasObra Social La CaixaEuropean Regional Development FundColabora Mujer AssociationFundación Amancio OrtegaRP93666https://www.ebi.ac.uk/biostudies/studies/S-EPMC11449485biostudies-literatureUnknown13The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (<i>BAZ2B</i> and <i>DDIAS</i>). A trans-ethnic meta-analysis revealed another neLifeNovel risk loci for COVID-19 hospitalization among admixed American populations.PMC11449485COV20_00622CGIEU0000219140A way of making EuropePI20/00876RTC-2017-6471-1COV20_1144PIFIISC20/57COV20_00181COV20/00792Martin VSanchez PMinguez PPaz-Artal ECuerda VMAndreu-Bernabeu ABoix-Palop LAguilera-Albesa Sde Bustamante ADAguilar CValencia-Ramos JBrion MMartinez-Nieto ORodriguez-Garcia JAArtiga MJBarreda-Sanchez MPorras-Hurtado GLResino STeper ASouto JCMartinez-Resendez MFYanez ZArango CHerrero MJBustos MCordero-Lorenzana MLFernandez-Villa TMartin-Lopez CBorja ALFernandez-Robelo ULeon SRHerrero-Gonzalez AGutierrez-Bautista JFLopez-Rodriguez RPerucho TBaptista-Rosas RCLuchessi ADRuiz-Hornillos JDarnaude MTPompa-Mera ENTorres-Tobar LParra EZarate RGago-Dominguez Mde Rojas IPita GGonzalez-Montelongo RRuiz-Cabello FDiz-de Almeida SCruz ROliveira SFQuintela IRuiz ABelhassen-Garcia MPujol ARiancho JAReal LMSCOURGE Cohort GroupFlores CPorras MSAguado JMAyuso CLapunzina PFarinas MCDe Martino-Rodriguez ABernaldo de Quiros FGSantos NPCAlmoguera BCortes-Sanchez JLMartinez-Lopez IPinsach-Abuin MRodriguez-Ruiz ECarracedo AFernandes MRCastano LMazzeu JFGonzalez-Penas JTamayo EJimenez-Sousa MAFernandez-Rodriguez ACarbonell CDel Campo-Perez VRyan PSoria JMArana-Arri EArranz MJParellada MMancebo EAlvarez BGGil-Fournier BNogueira Silbiger VMacias EMAlmadana VTenorio Castano JAOrtega-Paino ELorenzo-Salazar JMPerez PGonzalez-Neira ARodriguez-Artalejo FBrugada RDominguez-Garrido EMartinez-Perez ATaracido-Fernandez JCGuillen-Navarro Ede Heredia MLNevado JAlvarez NBezerra JFGomez-Arrue JCalderon EJPerez-Tomas MEUrioste MEiros RCastelao JEConde-Vicente RBezerra MACTamayo-Velasco ACorton MFernandez-Nestosa MJLattig MCPerez-Matute PRojas-Martinez AfalseNovel risk loci for COVID-19 hospitalization among admixed American populations.The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (<i>BAZ2B</i> and <i>DDIAS</i>). A trans-ethnic meta-analysis revealed another n2024-01-01T00:00:00Z2024 Oct2026-06-09T07:14:27.127Z2025-04-06T16:08:47.685ZS-EPMC114494853936137010.7554/eLife.93666