{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["DePoy LM"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","NIDA NIH HHS","Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)","Brain and Behavior Research Foundation","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","NIH HHS"],"pagination":["3117-3127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11449664"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(10)"],"pubmed_abstract":["Circadian rhythms are critical for human health and are highly conserved across species. Disruptions in these rhythms contribute to many diseases, including psychiatric disorders. Previous results suggest that circadian genes modulate behavior through specific cell types in the nucleus accumbens (NAc), particularly dopamine D1-expressing medium spiny neurons (MSNs). However, diurnal rhythms in transcript expression have not been investigated in NAc MSNs. In this study we identified and characterized rhythmic transcripts in D1- and D2-expressing neurons and compared rhythmicity results to homogenate as well as astrocyte samples taken from the NAc of male and female mice. We find that all cell types have transcripts with diurnal rhythms and that top rhythmic transcripts are largely core cloc"],"journal":["Molecular psychiatry"],"pubmed_title":["Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens."],"pmcid":["PMC11449664"],"funding_grant_id":["K99 DA055064","L60DA054665","MH111601","L60 DA054665","DA046346","MH106460","R01 MH106460","S10 OD028483","P50 DA046346","T32 NS007433","R01 MH111601","DA039865","DA055064","MH128763","K01 MH128763","29386","F32 DA046117","R01 DA039865","30823"],"pubmed_authors":["DePoy LM","Vadnie CA","Matthaei RC","Zong W","Yin R","Perez MS","Petersen KA","Becker-Krail D","Scott MR","Tseng GC","Ketchesin KD","McClung CA"],"additional_accession":[]},"is_claimable":false,"name":"Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens.","description":"Circadian rhythms are critical for human health and are highly conserved across species. Disruptions in these rhythms contribute to many diseases, including psychiatric disorders. Previous results suggest that circadian genes modulate behavior through specific cell types in the nucleus accumbens (NAc), particularly dopamine D1-expressing medium spiny neurons (MSNs). However, diurnal rhythms in transcript expression have not been investigated in NAc MSNs. In this study we identified and characterized rhythmic transcripts in D1- and D2-expressing neurons and compared rhythmicity results to homogenate as well as astrocyte samples taken from the NAc of male and female mice. We find that all cell types have transcripts with diurnal rhythms and that top rhythmic transcripts are largely core cloc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-01T09:04:25.847Z","creation":"2025-04-04T02:30:30.994Z"},"accession":"S-EPMC11449664","cross_references":{"pubmed":["38678086"],"doi":["10.1038/s41380-024-02569-7"]}}