biostudies-literatureMelgarejo JDNIA NIH HHS1985-1993https://www.ebi.ac.uk/biostudies/studies/S-EPMC11449671biostudies-literatureUnknown42(11)<h4>Objective</h4>A high office blood pressure (BP) is associated with cognitive decline. However, evidence of 24-h ambulatory BP monitoring is limited, and no studies have investigated whether longitudinal changes in 24-h BP are associated with cognitive decline. We aimed to test whether higher longitudinal changes in 24-h ambulatory BP measurements are associated with cognitive decline.<h4>Methods</h4>We included 437 dementia-free participants from the Maracaibo Aging Study with prospective data on 24-h ambulatory BP monitoring and cognitive function, which was assessed using the selective reminding test (SRT) and the Mini-Mental State Examination (MMSE). Using multivariate linear mixed regression models, we analyzed the association between longitudinal changes in measures of 24-h ambulaJournal of hypertensionAssociation of longitudinal changes in 24-h blood pressure level and variability with cognitive decline.PMC11449671P30 AG059305DP1 AG069870P30 AG066546R01 AG036469R03 AG054186Mena LJPatil DVatcheva KPTerwilliger JDMejia-Arango SBlangero JCharisis SChavez CAMavarez RPSatizabal CLAlliey-Rodriguez NSeshadri SMaestre GEGarcia AGaona CMelgarejo JDSilva ELee JHfalseAssociation of longitudinal changes in 24-h blood pressure level and variability with cognitive decline.<h4>Objective</h4>A high office blood pressure (BP) is associated with cognitive decline. However, evidence of 24-h ambulatory BP monitoring is limited, and no studies have investigated whether longitudinal changes in 24-h BP are associated with cognitive decline. We aimed to test whether higher longitudinal changes in 24-h ambulatory BP measurements are associated with cognitive decline.<h4>Methods</h4>We included 437 dementia-free participants from the Maracaibo Aging Study with prospective data on 24-h ambulatory BP monitoring and cognitive function, which was assessed using the selective reminding test (SRT) and the Mini-Mental State Examination (MMSE). Using multivariate linear mixed regression models, we analyzed the association between longitudinal changes in measures of 24-h ambula2024-01-01T00:00:00Z2024 Nov2026-06-05T08:38:43.94Z2025-04-06T16:26:20.798ZS-EPMC114496713914655310.1097/HJH.0000000000003824