biostudies-literatureUnknown11Luo C<h4>Background</h4>CMRtools is a software package that can be used to measure T2* values to diagnose liver iron overload, however, its accuracy in terms is affected by multiple factors, including goodness-of-fit (R² value), the number of echo time (TE) images, and the liver iron concentration (LIC). To investigate the effects of the R² value, the number of TE images, and the LIC on the accuracy of CMRtools software for measuring T2* values to diagnose liver iron overload (LIO).<h4>Materials and methods</h4>CMRtools software was used to measure liver T2* values among 108 thalassemia patients via the truncation method, and the R² values, the number of TE images, and T2* values were recorded. These values were subsequently converted into liver iron concentratiFrontiers in medicine1424294https://www.ebi.ac.uk/biostudies/studies/S-EPMC11449772biostudies-literatureAssessing the accuracy of CMRtools software for diagnosing liver iron overload in thalassemia patients: influencing factors and optimisation strategies.PMC11449772Peng FHuang CZhang YTang CPeng PLiang LNing XXu FLuo CfalseAssessing the accuracy of CMRtools software for diagnosing liver iron overload in thalassemia patients: influencing factors and optimisation strategies.<h4>Background</h4>CMRtools is a software package that can be used to measure T2* values to diagnose liver iron overload, however, its accuracy in terms is affected by multiple factors, including goodness-of-fit (R² value), the number of echo time (TE) images, and the liver iron concentration (LIC). To investigate the effects of the R² value, the number of TE images, and the LIC on the accuracy of CMRtools software for measuring T2* values to diagnose liver iron overload (LIO).<h4>Materials and methods</h4>CMRtools software was used to measure liver T2* values among 108 thalassemia patients via the truncation method, and the R² values, the number of TE images, and T2* values were recorded. These values were subsequently converted into liver iron concentrati2024-01-01T00:00:00Z20242025-04-26T08:45:06.792Z2025-04-06T12:52:29.42ZS-EPMC114497723937134010.3389/fmed.2024.1424294