{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stern S"],"funding":["NIA NIH HHS","NIMH NIH HHS","Israel Science Foundation","Israel Science Foundation (ISF)","NCI NIH HHS","JPB Foundation"],"pagination":["3208-3222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11449799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(10)"],"pubmed_abstract":["Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, about half of twin pairs are discordant for schizophrenia. To address the question of how and when concordance in monozygotic twins occur, we have obtained fibroblasts from two pairs of schizophrenia discordant twins (one sibling with schizophrenia while the second one is unaffected by schizophrenia) and three pairs of healthy twins (both of the siblings are healthy). We have prepared iPSC models for these 3 groups of patients with schizophrenia, unaffected co-twins, and the healthy twins. When the study started the co-twins were considered healthy and unaffected but bo"],"journal":["Molecular psychiatry"],"pubmed_title":["Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission."],"pmcid":["PMC11449799"],"funding_grant_id":["3252/21","P30 CA014195","F32 AG005651","U19 MH106434"],"pubmed_authors":["Choudhary A","Kahn RS","Wright R","Hussein Y","Zhang L","Reed P","Agarwal K","Wang M","Marchetto MC","Boks MP","Rethelyi JM","Sadis H","Roth JG","Baul TD","McCombie WR","Nayak R","Rosh I","Peles D","Coorapati S","Brennand KJ","Stern T","Hang Y","Hulshoff Pol H","Stern S","Tripathi U","Gage FH","Cordeiro D","Shemen A","Mendes APD"],"additional_accession":[]},"is_claimable":false,"name":"Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission.","description":"Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is a high concordance in monozygotic twins, about half of twin pairs are discordant for schizophrenia. To address the question of how and when concordance in monozygotic twins occur, we have obtained fibroblasts from two pairs of schizophrenia discordant twins (one sibling with schizophrenia while the second one is unaffected by schizophrenia) and three pairs of healthy twins (both of the siblings are healthy). We have prepared iPSC models for these 3 groups of patients with schizophrenia, unaffected co-twins, and the healthy twins. When the study started the co-twins were considered healthy and unaffected but bo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:30:08.249Z","creation":"2025-04-04T02:30:08.249Z"},"accession":"S-EPMC11449799","cross_references":{"pubmed":["38704507"],"doi":["10.1038/s41380-024-02561-1"]}}