{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loubiere V"],"funding":["European Molecular Biology Organization (EMBO)","Human Frontier Science Program (HFSP)"],"pagination":["8584"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11450171"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Genomic enhancers are key transcriptional regulators which, upon the binding of sequence-specific transcription factors, activate their cognate target promoters. Although enhancers have been extensively studied in isolation, a substantial number of genes have more than one simultaneously active enhancer, and it remains unclear how these cooperate to regulate transcription. Using Drosophila melanogaster S2 cells as a model, we assay the activities of more than a thousand individual enhancers and about a million enhancer pairs toward housekeeping and developmental core promoters with STARR-seq. We report that housekeeping and developmental enhancers show distinct modes of enhancer-enhancer cooperativity: while housekeeping enhancers are additive such that their combined activity mirrors the "],"journal":["Nature communications"],"pubmed_title":["Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila."],"pmcid":["PMC11450171"],"funding_grant_id":["790-2019","LT000926/2020"],"pubmed_authors":["Loubiere V","de Almeida BP","Stark A","Pagani M"],"additional_accession":[]},"is_claimable":false,"name":"Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila.","description":"Genomic enhancers are key transcriptional regulators which, upon the binding of sequence-specific transcription factors, activate their cognate target promoters. Although enhancers have been extensively studied in isolation, a substantial number of genes have more than one simultaneously active enhancer, and it remains unclear how these cooperate to regulate transcription. Using Drosophila melanogaster S2 cells as a model, we assay the activities of more than a thousand individual enhancers and about a million enhancer pairs toward housekeeping and developmental core promoters with STARR-seq. We report that housekeeping and developmental enhancers show distinct modes of enhancer-enhancer cooperativity: while housekeeping enhancers are additive such that their combined activity mirrors the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-18T13:06:27.487Z","creation":"2025-04-06T22:37:51.258Z"},"accession":"S-EPMC11450171","cross_references":{"pubmed":["39362902"],"doi":["10.1038/s41467-024-52921-2"]}}