{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bautista-Bautista G"],"funding":["Instituto Nacional de Perinatología \"Isidro Espinosa de los Reyes\", Ciudad de México, México."],"pagination":["645"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11451097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Escherichia coli (E. coli) is one of the main bacteria associated with preterm premature rupture of membranes by increasing pro-matrix metalloproteinase 9 (proMMP-9) and degradation of type IV collagen in human feto-maternal interface (HFMi). proMMP-9 is regulated by progesterone (P4) but it is unclear whether P4 inhibits proMMP in human maternal decidual (MDec). This study aimed to determine a role of P4 on proMMP-2 and - 9 and type IV collagen induced by E. coli infection in MDec.<h4>Methods</h4>Nine HFMi were mounted in a Transwell system. MDec was stimulated with P4 or E. coli for 3-, 6-, or 24-hours. proMMP-2, -9 and type IV collagen were assessed.<h4>Results</h4>Gelatin zymography revealed an increase in proMMP-9 after 3, 6, and 24 h of stimulating MDec with E. col"],"journal":["BMC pregnancy and childbirth"],"pubmed_title":["Escherichia coli induced matrix metalloproteinase-9 activity and type IV collagen degradation is regulated by progesterone in human maternal decidual."],"pmcid":["PMC11451097"],"funding_grant_id":["2017-2-82"],"pubmed_authors":["Lara-Pereyra I","Flores-Herrera H","Villeda-Gabriel G","Acuna-Gonzalez RJ","Bautista-Bautista G","Diaz-Ruiz O","Palafox-Vargas ML","Garcia-Lopez G","Salguero-Zacarias S","Osorio-Caballero M"],"additional_accession":[]},"is_claimable":false,"name":"Escherichia coli induced matrix metalloproteinase-9 activity and type IV collagen degradation is regulated by progesterone in human maternal decidual.","description":"<h4>Background</h4>Escherichia coli (E. coli) is one of the main bacteria associated with preterm premature rupture of membranes by increasing pro-matrix metalloproteinase 9 (proMMP-9) and degradation of type IV collagen in human feto-maternal interface (HFMi). proMMP-9 is regulated by progesterone (P4) but it is unclear whether P4 inhibits proMMP in human maternal decidual (MDec). This study aimed to determine a role of P4 on proMMP-2 and - 9 and type IV collagen induced by E. coli infection in MDec.<h4>Methods</h4>Nine HFMi were mounted in a Transwell system. MDec was stimulated with P4 or E. coli for 3-, 6-, or 24-hours. proMMP-2, -9 and type IV collagen were assessed.<h4>Results</h4>Gelatin zymography revealed an increase in proMMP-9 after 3, 6, and 24 h of stimulating MDec with E. col","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-07T08:12:27.356Z","creation":"2025-04-04T02:00:46.846Z"},"accession":"S-EPMC11451097","cross_references":{"pubmed":["39367340"],"doi":["10.1186/s12884-024-06847-8"]}}