{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu W"],"funding":["Medical Research Council"],"pagination":["e15279"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11451341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(6)"],"pubmed_abstract":["<h4>Aims</h4>Evidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population of stromal cells within islets of Langerhans - islet stellate cells (ISCs) - which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.<h4>Methods</h4>ISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell-surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co-"],"journal":["Diabetic medicine : a journal of the British Diabetic Association"],"pubmed_title":["Mouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function."],"pmcid":["PMC11451341"],"funding_grant_id":["MR/W002876/1"],"pubmed_authors":["King AJF","Jones PM","Wang C","Li R","Hong TW","Zhou Y","Sun Z","Liu X","Wang T","Liang J","Persaud SJ","Liu B","Ni C","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"Mouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function.","description":"<h4>Aims</h4>Evidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population of stromal cells within islets of Langerhans - islet stellate cells (ISCs) - which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.<h4>Methods</h4>ISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell-surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-18T14:35:33.298Z","creation":"2025-04-07T00:48:10.71Z"},"accession":"S-EPMC11451341","cross_references":{"pubmed":["38185936"],"doi":["10.1111/dme.15279"]}}