biostudies-literatureXu WMedical Research Councile15279https://www.ebi.ac.uk/biostudies/studies/S-EPMC11451341biostudies-literatureUnknown41(6)<h4>Aims</h4>Evidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population of stromal cells within islets of Langerhans - islet stellate cells (ISCs) - which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.<h4>Methods</h4>ISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell-surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co-Diabetic medicine : a journal of the British Diabetic AssociationMouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function.PMC11451341MR/W002876/1King AJFJones PMWang CLi RHong TWZhou YSun ZLiu XWang TLiang JPersaud SJLiu BNi CXu WfalseMouse islet-derived stellate cells are similar to, but distinct from, mesenchymal stromal cells and influence the beta cell function.<h4>Aims</h4>Evidence is accumulating of the therapeutic benefits of mesenchymal stromal cells (MSCs) in diabetes-related conditions. We have identified a novel population of stromal cells within islets of Langerhans - islet stellate cells (ISCs) - which have a similar morphology to MSCs. In this study we characterize mouse ISCs and compare their morphology and function to MSCs to determine whether ISCs may also have therapeutic potential in diabetes.<h4>Methods</h4>ISCs isolated from mouse islets were compared to mouse bone marrow MSCs by analysis of cell morphology; expression of cell-surface markers and extracellular matrix (ECM) components; proliferation; apoptosis; paracrine activity; and differentiation into adipocytes, chondrocytes and osteocytes. We also assessed the effects of co-2024-01-01T00:00:00Z2024 Jun2025-04-18T14:35:33.298Z2025-04-07T00:48:10.71ZS-EPMC114513413818593610.1111/dme.15279