{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tao C"],"funding":["NIA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)","U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders","U.S. Department of Health & Human Services | NIH | National Eye Institute","NEI NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","NIDCD NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)"],"pagination":["8575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11452203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Dysregulation of brain homeostasis is associated with neuropsychiatric conditions such as major depressive disorder. However, underlying neural-circuit mechanisms remain not well-understood. We show in mice that chronic restraint stress (CRS) and social defeat stress (SDS) are both associated with disruption of excitation (E)-inhibition (I) balance, with increased E/I ratios, in medial preoptic area (MPOA) circuits, but through affecting different neuronal types. CRS results in elevated activity in glutamatergic neurons, and their suppression mitigates CRS-induced depressive-like behaviors. Paraventricular hypothalamic input to these neurons contributes to induction but not expression of depressive-like behaviors. Their projections to ventral tegmental area and periaqueductal gray/dorsal r"],"journal":["Nature communications"],"pubmed_title":["Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states."],"pmcid":["PMC11452203"],"funding_grant_id":["EY019049","MH116990","U01 MH116990","RF1 NS132912","R01 DC020887","R01 DC008983","R01DC008983","RF1NS132912","R01 EY019049","R01 AG089756"],"pubmed_authors":["Zhang GW","Sun WJ","Huang JJ","Zhang LI","Tao C","Tao HW"],"additional_accession":[]},"is_claimable":false,"name":"Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states.","description":"Dysregulation of brain homeostasis is associated with neuropsychiatric conditions such as major depressive disorder. However, underlying neural-circuit mechanisms remain not well-understood. We show in mice that chronic restraint stress (CRS) and social defeat stress (SDS) are both associated with disruption of excitation (E)-inhibition (I) balance, with increased E/I ratios, in medial preoptic area (MPOA) circuits, but through affecting different neuronal types. CRS results in elevated activity in glutamatergic neurons, and their suppression mitigates CRS-induced depressive-like behaviors. Paraventricular hypothalamic input to these neurons contributes to induction but not expression of depressive-like behaviors. Their projections to ventral tegmental area and periaqueductal gray/dorsal r","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-09T07:20:36.827Z","creation":"2025-04-06T22:33:56.004Z"},"accession":"S-EPMC11452203","cross_references":{"pubmed":["39362860"],"doi":["10.1038/s41467-024-52727-2"]}}