{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Karthik K"],"funding":["Department of Biotechnology, Ministry of Science and Technology, India"],"pagination":["257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11452369"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["<i>Clostridioides difficile</i>, a zoonotic pathogen causing enteric diseases in different animals and humans. A comprehensive study on the presence of toxin genes and antimicrobial resistance genes based on genome data of <i>C. difficile</i> in animals is scanty. In the present study, a total of 15 <i>C. difficile</i> isolates were recovered from dogs and isolates with toxin genes (D1, CD15 and CD26) along with two other non-toxigenic strains (CD28, CD32) were used for whole genome sequencing and comparative genomics. Sequence type-based clustering was noted in the whole genome phylogeny with 4 known multi-locus sequence typing (MLST) clades namely I, II, IV, and V and a cryptic clade. ST11 and ST54 were reported for the 2<sup>nd</sup> time worldwide in dogs. Out of 109 genomes used in th"],"journal":["3 Biotech"],"pubmed_title":["Comparative genomics of zoonotic pathogen &lt;i&gt;Clostridioides difficile&lt;/i&gt; of animal origin to understand its diversity."],"pmcid":["PMC11452369"],"funding_grant_id":["BT/PR25444/NER/95/1200/2017"],"pubmed_authors":["Anbazhagan S","Sharma RK","Karthik K","Manoharan S","Priyadharshini MLM"],"additional_accession":[]},"is_claimable":false,"name":"Comparative genomics of zoonotic pathogen &lt;i&gt;Clostridioides difficile&lt;/i&gt; of animal origin to understand its diversity.","description":"<i>Clostridioides difficile</i>, a zoonotic pathogen causing enteric diseases in different animals and humans. A comprehensive study on the presence of toxin genes and antimicrobial resistance genes based on genome data of <i>C. difficile</i> in animals is scanty. In the present study, a total of 15 <i>C. difficile</i> isolates were recovered from dogs and isolates with toxin genes (D1, CD15 and CD26) along with two other non-toxigenic strains (CD28, CD32) were used for whole genome sequencing and comparative genomics. Sequence type-based clustering was noted in the whole genome phylogeny with 4 known multi-locus sequence typing (MLST) clades namely I, II, IV, and V and a cryptic clade. ST11 and ST54 were reported for the 2<sup>nd</sup> time worldwide in dogs. Out of 109 genomes used in th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-15T03:12:06.392Z","creation":"2026-05-15T03:07:58.209Z"},"accession":"S-EPMC11452369","cross_references":{"pubmed":["39372495"],"doi":["10.1007/s13205-024-04102-7"]}}