{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wen J"],"funding":["NIA NIH HHS","NIH HHS"],"pagination":["420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11455841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Alzheimer's disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the \"diffuse-AD\" (R1) dimension shows widespread brain atrophy, and the \"MTL-AD\" (R2) dimension displays focal medial temporal lobe (MTL) atrophy. Critically, only R2 was associated with widely known sporadic AD genetic risk factors (e.g., APOE ε4) in MCI and AD patients at baseline. We then independently detected the presence of the two dimensions in the early stages by deploying the trained model in the general population and two cognitively unimpaired cohorts of asymptomatic partici"],"journal":["Translational psychiatry"],"pubmed_title":["Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum."],"pmcid":["PMC11455841"],"funding_grant_id":["R01 AG067103","R01 AG080821","R01 AG066650","S10 OD032285","R01 AG085571","P30 AG066546","RF1 AG054409","R01 AG068193","R01 AG083865"],"pubmed_authors":["Shen L","LaMontagne P","Shou H","Marcus DS","Varol E","Davatzikos C","Wen J","Bilgel M","Ferrucci L","Grabe HJ","Benzinger TL","Habes M","Wolk D","Chen J","Erus G","Nasrallah IM","Hohman TJ","Bryan RN","Yang Z","Boquet-Pujadas A","Sotiras A","Tosun D","Thompson PM","Gollub R","Maruff P","Toga AW","Johnson SC","Villeneuve S","Bao J","An Y","Resnick SM","Bergman M","Fripp J","Saykin AJ","Albert MS","Espeland M","Fan Y","Wittfeld K","Austin TR","Hwang G","Singh A","Masters CL","Heckbert SR","Srinivasan D","Abdulkadir A","Morris JC","Zhou Z","Mamourian E","Cui Y","Launer LJ"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.","description":"Alzheimer's disease (AD) is associated with heterogeneous atrophy patterns. We employed a semi-supervised representation learning technique known as Surreal-GAN, through which we identified two latent dimensional representations of brain atrophy in symptomatic mild cognitive impairment (MCI) and AD patients: the \"diffuse-AD\" (R1) dimension shows widespread brain atrophy, and the \"MTL-AD\" (R2) dimension displays focal medial temporal lobe (MTL) atrophy. Critically, only R2 was associated with widely known sporadic AD genetic risk factors (e.g., APOE ε4) in MCI and AD patients at baseline. We then independently detected the presence of the two dimensions in the early stages by deploying the trained model in the general population and two cognitively unimpaired cohorts of asymptomatic partici","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-02T23:25:07.537Z","creation":"2025-04-07T00:47:58.951Z"},"accession":"S-EPMC11455841","cross_references":{"pubmed":["39368996"],"doi":["10.1038/s41398-024-03121-5"]}}