{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salihovic S"],"funding":["Region Örebro län","Örebro University","Knowledge Foundation, Sweden","Knowledge Foundation"],"pagination":["111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11455889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(5)"],"pubmed_abstract":["<h4>Background</h4>Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.<h4>Objective</h4>The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequen"],"journal":["Metabolomics : Official journal of the Metabolomic Society"],"pubmed_title":["Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance."],"pmcid":["PMC11455889"],"funding_grant_id":["2020-0257","OLL-986200","2016-0044","2018-0133"],"pubmed_authors":["Kruse R","Eklund D","Salihovic S","Hyotylainen T","Sarndahl E","Kurland L","Wallgren U"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.","description":"<h4>Background</h4>Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.<h4>Objective</h4>The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequen","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T09:36:23.815Z","creation":"2025-04-06T09:33:28.611Z"},"accession":"S-EPMC11455889","cross_references":{"pubmed":["39369060"],"doi":["10.1007/s11306-024-02172-5"]}}