biostudies-literatureSalihovic SRegion Örebro länÖrebro UniversityKnowledge Foundation, SwedenKnowledge Foundation111https://www.ebi.ac.uk/biostudies/studies/S-EPMC11455889biostudies-literatureUnknown20(5)<h4>Background</h4>Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.<h4>Objective</h4>The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequenMetabolomics : Official journal of the Metabolomic SocietyExploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.PMC114558892020-0257OLL-9862002016-00442018-0133Kruse REklund DSalihovic SHyotylainen TSarndahl EKurland LWallgren UfalseExploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.<h4>Background</h4>Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.<h4>Objective</h4>The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequen2024-01-01T00:00:00Z2024 Oct2026-07-15T09:36:23.815Z2025-04-06T09:33:28.611ZS-EPMC114558893936906010.1007/s11306-024-02172-5