biostudies-literatureUnknown14(1)Dey PHelmholtz-Zentrum für Umweltforschung GmbH - UFZMicropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of the pesticide lindane and multiple metals (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in Aspergillus fumigatus PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 of which were consistently present under both stress conditions. Specifically, Cu-Zn superoxide dismutase and heat shock proteins were up-regulated to counter oxidative stress and protein misfolding. Proteins involved in intracellular trafficking, secretion, and vesicular transport; RNA processing and modification showed enhanced abundance and regulating stress response pathways. Additionally, haloalkane dehalogenase anScientific reports23171https://www.ebi.ac.uk/biostudies/studies/S-EPMC11457522biostudies-literatureUnveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics.PMC11457522Malik ADey PHaange SBvon Bergen MJehmlich NSingh DKfalseUnveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics.Micropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of the pesticide lindane and multiple metals (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in Aspergillus fumigatus PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 of which were consistently present under both stress conditions. Specifically, Cu-Zn superoxide dismutase and heat shock proteins were up-regulated to counter oxidative stress and protein misfolding. Proteins involved in intracellular trafficking, secretion, and vesicular transport; RNA processing and modification showed enhanced abundance and regulating stress response pathways. Additionally, haloalkane dehalogenase an2024-01-01T00:00:00Z2024 Oct2026-06-16T03:10:27.311Z2025-04-06T12:49:18.076ZS-EPMC114575223936903510.1038/s41598-024-74517-y