{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei X"],"funding":["Natural Science Foundation of Fujian Province","National Natural Science Foundation of China"],"pagination":["RP96445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11458174"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore, understanding the regulatory mechanisms of PD-L1, particularly in the context of super-enhancers (SEs) and zinc finger protein 36 ring finger protein-like 1 (ZFP36L1) RNA-binding protein, is crucial. In this study, we performed H3K27ac Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing, investigated the heterogeneity of SEs between two GC subtypes with differential growth patterns, and revealed the immune escape signatures driven by ZFP36L1-SE in infiltrative GC through SEs inhibitors treatment. The regulation of ZFP36L1 to PD-L1 wa"],"journal":["eLife"],"pubmed_title":["Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer."],"pmcid":["PMC11458174"],"funding_grant_id":["No. 2023J011594","No. 2021J02056","No. 2020CXB048","No. 82272894","2021D026","No. 81871979"],"pubmed_authors":["Liu J","Xie W","Hou J","Zhuo H","Cai J","Wei X","Lin L","Wang K","Cheng J","Cai W"],"additional_accession":[]},"is_claimable":false,"name":"Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer.","description":"Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore, understanding the regulatory mechanisms of PD-L1, particularly in the context of super-enhancers (SEs) and zinc finger protein 36 ring finger protein-like 1 (ZFP36L1) RNA-binding protein, is crucial. In this study, we performed H3K27ac Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing, investigated the heterogeneity of SEs between two GC subtypes with differential growth patterns, and revealed the immune escape signatures driven by ZFP36L1-SE in infiltrative GC through SEs inhibitors treatment. The regulation of ZFP36L1 to PD-L1 wa","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T04:03:38.565Z","creation":"2025-04-04T01:54:34.524Z"},"accession":"S-EPMC11458174","cross_references":{"pubmed":["39373630"],"doi":["10.7554/eLife.96445"]}}