{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Yang M"],"pubmed_abstract":["<i>Mycoplasma bovis</i> pneumonia is a highly contagious respiratory infection caused by <i>Mycoplasma bovis</i>. It is particularly prevalent in calves, posing a significant threat to animal health and leading to substantial economic losses. Dang-Shen-Yu-Xing decoction is often used to treat this condition in veterinary clinics. It exhibits robust anti-inflammatory effects and can alleviate pulmonary fibrosis. However, its mechanism of action remains unclear. Therefore, this study aimed to preliminarily explore the molecular mechanism of Dang-Shen-Yu-Xing decoction for treating <i>mycoplasma</i> pneumonia in calves through a combination of network pharmacology, molecular docking, molecular dynamics simulation methods, and experimental validation. The active components and related targets "],"journal":["Frontiers in veterinary science"],"pagination":["1431233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11458528"],"repository":["biostudies-literature"],"pubmed_title":["Molecular mechanism of Dang-Shen-Yu-Xing decoction against <i>Mycoplasma bovis</i> pneumonia based on network pharmacology, molecular docking, molecular dynamics simulations and experimental verification."],"pmcid":["PMC11458528"],"pubmed_authors":["Li Y","Guo L","He S","Guo Y","Yang M","Qi Y","Yang F","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Molecular mechanism of Dang-Shen-Yu-Xing decoction against <i>Mycoplasma bovis</i> pneumonia based on network pharmacology, molecular docking, molecular dynamics simulations and experimental verification.","description":"<i>Mycoplasma bovis</i> pneumonia is a highly contagious respiratory infection caused by <i>Mycoplasma bovis</i>. It is particularly prevalent in calves, posing a significant threat to animal health and leading to substantial economic losses. Dang-Shen-Yu-Xing decoction is often used to treat this condition in veterinary clinics. It exhibits robust anti-inflammatory effects and can alleviate pulmonary fibrosis. However, its mechanism of action remains unclear. Therefore, this study aimed to preliminarily explore the molecular mechanism of Dang-Shen-Yu-Xing decoction for treating <i>mycoplasma</i> pneumonia in calves through a combination of network pharmacology, molecular docking, molecular dynamics simulation methods, and experimental validation. The active components and related targets ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-07T07:39:13.663Z","creation":"2025-04-04T01:54:19.114Z"},"accession":"S-EPMC11458528","cross_references":{"pubmed":["39380772"],"doi":["10.3389/fvets.2024.1431233"]}}