biostudies-literatureUnknown11Yang M<i>Mycoplasma bovis</i> pneumonia is a highly contagious respiratory infection caused by <i>Mycoplasma bovis</i>. It is particularly prevalent in calves, posing a significant threat to animal health and leading to substantial economic losses. Dang-Shen-Yu-Xing decoction is often used to treat this condition in veterinary clinics. It exhibits robust anti-inflammatory effects and can alleviate pulmonary fibrosis. However, its mechanism of action remains unclear. Therefore, this study aimed to preliminarily explore the molecular mechanism of Dang-Shen-Yu-Xing decoction for treating <i>mycoplasma</i> pneumonia in calves through a combination of network pharmacology, molecular docking, molecular dynamics simulation methods, and experimental validation. The active components and related targets Frontiers in veterinary science1431233https://www.ebi.ac.uk/biostudies/studies/S-EPMC11458528biostudies-literatureMolecular mechanism of Dang-Shen-Yu-Xing decoction against <i>Mycoplasma bovis</i> pneumonia based on network pharmacology, molecular docking, molecular dynamics simulations and experimental verification.PMC11458528Li YGuo LHe SGuo YYang MQi YYang FLiu FfalseMolecular mechanism of Dang-Shen-Yu-Xing decoction against <i>Mycoplasma bovis</i> pneumonia based on network pharmacology, molecular docking, molecular dynamics simulations and experimental verification.<i>Mycoplasma bovis</i> pneumonia is a highly contagious respiratory infection caused by <i>Mycoplasma bovis</i>. It is particularly prevalent in calves, posing a significant threat to animal health and leading to substantial economic losses. Dang-Shen-Yu-Xing decoction is often used to treat this condition in veterinary clinics. It exhibits robust anti-inflammatory effects and can alleviate pulmonary fibrosis. However, its mechanism of action remains unclear. Therefore, this study aimed to preliminarily explore the molecular mechanism of Dang-Shen-Yu-Xing decoction for treating <i>mycoplasma</i> pneumonia in calves through a combination of network pharmacology, molecular docking, molecular dynamics simulation methods, and experimental validation. The active components and related targets 2024-01-01T00:00:00Z20242026-06-07T07:39:13.663Z2025-04-04T01:54:19.114ZS-EPMC114585283938077210.3389/fvets.2024.1431233