biostudies-literatureUnknown5Wang E<h4>Objective</h4>The association between autoimmune diseases and chronic rhinosinusitis in observational studies remains unclear. This study aimed to explore the genetic correlation between chronic rhinosinusitis and autoimmune diseases.<h4>Methods</h4>We employed Mendelian randomization (MR) analysis and linkage disequilibrium score regression (LDSC) to investigate causal relationships and genetic correlations between autoimmune phenotypes and chronic rhinosinusitis. Additionally, transcriptome-wide association (TWAS) analysis was conducted to identify the shared genes between the two conditions to demonstrate their relationship. The CRS GWAS (genome-wide association study) data and other autoimmune diseases were retrieved from ieuOpenGWAS (https://gwas.mrcieu.ac.uk/), the FinnGen allianFrontiers in allergy1387774https://www.ebi.ac.uk/biostudies/studies/S-EPMC11458559biostudies-literatureGenetic correlation between chronic sinusitis and autoimmune diseases.PMC11458559Wang MCao ZWang ESun YZhao HfalseGenetic correlation between chronic sinusitis and autoimmune diseases.<h4>Objective</h4>The association between autoimmune diseases and chronic rhinosinusitis in observational studies remains unclear. This study aimed to explore the genetic correlation between chronic rhinosinusitis and autoimmune diseases.<h4>Methods</h4>We employed Mendelian randomization (MR) analysis and linkage disequilibrium score regression (LDSC) to investigate causal relationships and genetic correlations between autoimmune phenotypes and chronic rhinosinusitis. Additionally, transcriptome-wide association (TWAS) analysis was conducted to identify the shared genes between the two conditions to demonstrate their relationship. The CRS GWAS (genome-wide association study) data and other autoimmune diseases were retrieved from ieuOpenGWAS (https://gwas.mrcieu.ac.uk/), the FinnGen allian2024-01-01T00:00:00Z20242026-06-02T23:07:26.212Z2025-04-04T01:53:40.391ZS-EPMC114585593938151010.3389/falgy.2024.1387774