{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mato S"],"funding":["Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)","Michael Smith Foundation for Health Research (MSFHR)","Generalitat de Catalunya (Government of Catalonia)","Government of Catalonia | Departament de Salut, Generalitat de Catalunya"],"pagination":["171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11458770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and a subset of high-grade tumors with features intermediate between these entities whose genetic and molecular profiles have not been completely elucidated. In this study, we have characterized 37 aggressive B-NHL in CAYA, 33 with high-grade morphology, and 4 DLBCL with MYC rearrangement (MYC-R), using targeted next-generation sequencing and the aggressive lymphoma gene expression germinal center B-cell-like (GCB), activated B-cell-like (ABC), and dark zone signatures (DZsig). Twenty-two tumors had MYC-R without BCL2 breaks, and two MYC-non-R cases had BCL6 translocations. MYC-R cases, including DLBCL, carried BL-related muta"],"journal":["Blood cancer journal"],"pubmed_title":["MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma."],"pmcid":["PMC11458770"],"funding_grant_id":["Investigo 100028TC7","ICREA Academia Researcher","2021-SGR-01172","FI22/00063","PERIS SL017/20/000204","PI18/00471, PI21/00479, MS18/00015","Health Professional Investigator Award"],"pubmed_authors":["Astigarraga I","Andres M","Verdu-Amoros J","Ortega MJ","Colmenero A","Garcia N","Balague O","Perez-Alonso V","Wang L","Campo E","Mato S","Quiroga E","Castrejon-de-Anta N","Salmeron-Villalobos J","Celis V","Ramis-Zaldivar JE","Jiang A","Scott DW","Conde N","Salaverria I","Nadeu F","Galera A","Carita L"],"additional_accession":[]},"is_claimable":false,"name":"MYC-rearranged mature B-cell lymphomas in children and young adults are molecularly Burkitt Lymphoma.","description":"Aggressive B-cell non-Hodgkin lymphomas (NHL) in children, adolescents, and young adults (CAYA) include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and a subset of high-grade tumors with features intermediate between these entities whose genetic and molecular profiles have not been completely elucidated. In this study, we have characterized 37 aggressive B-NHL in CAYA, 33 with high-grade morphology, and 4 DLBCL with MYC rearrangement (MYC-R), using targeted next-generation sequencing and the aggressive lymphoma gene expression germinal center B-cell-like (GCB), activated B-cell-like (ABC), and dark zone signatures (DZsig). Twenty-two tumors had MYC-R without BCL2 breaks, and two MYC-non-R cases had BCL6 translocations. MYC-R cases, including DLBCL, carried BL-related muta","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-03-27T16:38:31.633Z","creation":"2025-04-04T02:29:49.941Z"},"accession":"S-EPMC11458770","cross_references":{"pubmed":["39375391"],"doi":["10.1038/s41408-024-01153-0"]}}