biostudies-literatureHutchinson RBarts Charitye002675https://www.ebi.ac.uk/biostudies/studies/S-EPMC11459353biostudies-literatureUnknown8(1)<h4>Background</h4>Intestinal dysbiosis is implicated in the pathogenesis of necrotising enterocolitis and late-onset sepsis in preterm babies. The provision of non-invasive positive pressure ventilation is a common clinical intervention in preterm babies, and may be hypothesised to adversely affect intestinal bacterial growth, through increased aerophagia and induction of a hyperoxic intestinal environment; however this relationship has not been previously well characterised.<h4>Methodology</h4>In this prospectively recruited cohort study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess within-subject changes in microbiome development around the time of transitioning from non-invasive positive pressure respiratory support to uBMJ paediatrics openChanges in the intestinal microbiome of the preterm baby associated with stopping non-invasive pressure support: a prospective cohort study.PMC11459353764.2306Stacey FFleming PHutchinson RAnsbro KWade WMillar MCosteloe KfalseChanges in the intestinal microbiome of the preterm baby associated with stopping non-invasive pressure support: a prospective cohort study.<h4>Background</h4>Intestinal dysbiosis is implicated in the pathogenesis of necrotising enterocolitis and late-onset sepsis in preterm babies. The provision of non-invasive positive pressure ventilation is a common clinical intervention in preterm babies, and may be hypothesised to adversely affect intestinal bacterial growth, through increased aerophagia and induction of a hyperoxic intestinal environment; however this relationship has not been previously well characterised.<h4>Methodology</h4>In this prospectively recruited cohort study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess within-subject changes in microbiome development around the time of transitioning from non-invasive positive pressure respiratory support to u2024-01-01T00:00:00Z2024 Oct2026-06-07T08:12:25.576Z2025-04-04T02:00:42.717ZS-EPMC114593533936279310.1136/bmjpo-2024-002675