{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shan X"],"funding":["NIDDK NIH HHS","Michael Smith Foundation for Health Research","NIDDK"],"pagination":["101378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11459652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(5)"],"pubmed_abstract":["<h4>Background & aims</h4>Addition of sialic acids (sialylation) to glycoconjugates is a common capping step of glycosylation. Our study aims to determine the roles of the overall sialylation in intestinal mucosal homeostasis.<h4>Methods</h4>Mice with constitutive deletion of intestinal epithelial sialylation (IEC Slc35a1<sup>-/-</sup> mice) and mice with inducible deletion of sialylation in intestinal epithelium (TM-IEC Slc35a1<sup>-/-</sup> mice) were generated, which were used to determine the roles of overall sialylation in intestinal mucosal homeostasis by ex vivo and mutiomics studies.<h4>Results</h4>IEC Slc35a1<sup>-/-</sup> mice developed mild spontaneous microbiota-dependent colitis. Additionally, 30% of IEC Slc35a1<sup>-/-</sup> mice had spontaneous tumors in the rectum greater t"],"journal":["Cellular and molecular gastroenterology and hepatology"],"pubmed_title":["Ablation of Intestinal Epithelial Sialylation Predisposes to Acute and Chronic Intestinal Inflammation in Mice."],"pmcid":["PMC11459652"],"funding_grant_id":["R01 DK085691"],"pubmed_authors":["Nitin","Ghosh S","Shan X","Letef CL","Zandberg W","Kniffen D","Xia L","Bergstrom KS","Gao L","Rathore S","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Ablation of Intestinal Epithelial Sialylation Predisposes to Acute and Chronic Intestinal Inflammation in Mice.","description":"<h4>Background & aims</h4>Addition of sialic acids (sialylation) to glycoconjugates is a common capping step of glycosylation. Our study aims to determine the roles of the overall sialylation in intestinal mucosal homeostasis.<h4>Methods</h4>Mice with constitutive deletion of intestinal epithelial sialylation (IEC Slc35a1<sup>-/-</sup> mice) and mice with inducible deletion of sialylation in intestinal epithelium (TM-IEC Slc35a1<sup>-/-</sup> mice) were generated, which were used to determine the roles of overall sialylation in intestinal mucosal homeostasis by ex vivo and mutiomics studies.<h4>Results</h4>IEC Slc35a1<sup>-/-</sup> mice developed mild spontaneous microbiota-dependent colitis. Additionally, 30% of IEC Slc35a1<sup>-/-</sup> mice had spontaneous tumors in the rectum greater t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-14T19:40:30.01Z","creation":"2025-04-19T19:25:51.317Z"},"accession":"S-EPMC11459652","cross_references":{"pubmed":["38992465"],"doi":["10.1016/j.jcmgh.2024.101378"]}}