biostudies-literatureJiang XHealth and Medical Research FundNational Natural Science Foundation of China1847-1855https://www.ebi.ac.uk/biostudies/studies/S-EPMC11461585biostudies-literatureUnknown68(9)Febrile seizures are convulsions predominately occurring in young children. The effects of various exposomes, including influenza infection and external environmental factors, on febrile seizures have not been well-studied. In this study, we elucidated the relationships between ambient temperature, air pollutants, influenza infection, and febrile seizures using 22-year territory-wide hospitalization data in Hong Kong. The aggregated data were matched with the meteorological records and air pollutant concentrations. All-type and type-specific influenza-like illness positive (ILI+) rates were used as proxies for influenza activity. Distributed lag non-linear model in conjunction with the quasi-poisson generalized additive model was used to examine the associations of interest. According to tInternational journal of biometeorologyEffect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis.PMC114615857197416519181132INF-CUHK-1Li CLao XQYue QJiang XLin GChong KCWang YWei YfalseEffect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis.Febrile seizures are convulsions predominately occurring in young children. The effects of various exposomes, including influenza infection and external environmental factors, on febrile seizures have not been well-studied. In this study, we elucidated the relationships between ambient temperature, air pollutants, influenza infection, and febrile seizures using 22-year territory-wide hospitalization data in Hong Kong. The aggregated data were matched with the meteorological records and air pollutant concentrations. All-type and type-specific influenza-like illness positive (ILI+) rates were used as proxies for influenza activity. Distributed lag non-linear model in conjunction with the quasi-poisson generalized additive model was used to examine the associations of interest. According to t2024-01-01T00:00:00Z2024 Sep2026-07-14T20:41:01.404Z2025-04-03T23:48:25.875ZS-EPMC114615853881944310.1007/s00484-024-02711-8