biostudies-literatureTomlinson MMNational Institute of Environmental Health SciencesNIEHS NIH HHS1367-1381https://www.ebi.ac.uk/biostudies/studies/S-EPMC11461597biostudies-literatureUnknown35(10)<h4>Purpose</h4>Cancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms affecting cancer. The role of known metal carcinogens (i.e., cadmium, arsenic, nickel, chromium(VI)) in breast and colorectal carcinogenesis is largely unknown. Historically marginalized communities are disproportionately exposed to metals, which could explain cancer disparities. We examined area-based metal exposures and odds of residing in breast and colorectal cancer hotspots utilizing state tumor registry data and described the characteristics of those living in heavy metal-associated cancer hotspots.<h4>Methods</h4>Breast and colorectal cancer hotspots were mapped across Kentucky, and area-based ambient metal exposure to cadmium, Cancer causes & control : CCCHeavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics.PMC11461597T32 ES011564P30 ES030283Tomlinson MMGuinn BDuPre NCRuther MPugh FIyer HSKavalukas SLaden FAbraham SNewton JDNail ANUdoh KEllis CTTamimi RMStates JCfalseHeavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics.<h4>Purpose</h4>Cancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms affecting cancer. The role of known metal carcinogens (i.e., cadmium, arsenic, nickel, chromium(VI)) in breast and colorectal carcinogenesis is largely unknown. Historically marginalized communities are disproportionately exposed to metals, which could explain cancer disparities. We examined area-based metal exposures and odds of residing in breast and colorectal cancer hotspots utilizing state tumor registry data and described the characteristics of those living in heavy metal-associated cancer hotspots.<h4>Methods</h4>Breast and colorectal cancer hotspots were mapped across Kentucky, and area-based ambient metal exposure to cadmium, 2024-01-01T00:00:00Z2024 Oct2026-07-14T20:39:44.551Z2025-04-04T02:30:51.928ZS-EPMC114615973891670310.1007/s10552-024-01894-0