biostudies-literatureZhou XDNational Natural Science Foundation of ChinaNational Key Research and Development Program of China102848https://www.ebi.ac.uk/biostudies/studies/S-EPMC11462227biostudies-literatureUnknown76<h4>Background</h4>Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood.<h4>Methods</h4>We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m² for individuals aged ≥20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, sex, year, geographical location, and SDI.<h4>Findings</h4>From 1990 to 2EClinicalMedicineBurden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.PMC114622272023YFA18008018207058882370577Chan WKZuluaga MCasajoana APik-Shan Kong AWong YJRuiz-Ucar EZhang HThaher OOviedo RJToro-Huamanchumo CJAl Momani HAbdelbaki TNSzepietowski OZheng MHPerera NAl-Busafi SAJumaev NAOspanov OGarcia MMendez-Sanchez NSharara AILim-Loo MCYang WMisra AFouad YOcama PPrasad AYen Kok KYAbu-Abeid ATargher GRobertson AGRyan JDValenti LAlswat KMolina GAMantzoros CSByrne CDKızılkaya MCLonardo AAtaya KAli AKatsouras CSZhou XDOpio CKTreeprasertsuk SLuo FSookoian SAdams LAbbas SIViveiros OChen QFfalseBurden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.<h4>Background</h4>Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood.<h4>Methods</h4>We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m² for individuals aged ≥20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, sex, year, geographical location, and SDI.<h4>Findings</h4>From 1990 to 22024-01-01T00:00:00Z2024 Oct2025-04-26T10:26:26.693Z2025-04-06T13:21:30.893ZS-EPMC114622273938616010.1016/j.eclinm.2024.102848