{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma K"],"funding":["National Natural Science Foundation of China"],"pagination":["1378758"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11463157"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<h4>Introduction</h4>Podophyllotoxin (PPT) is a high-content and high-activity compound extracted from the traditional Chinese medicinal plant <i>Dysosma versipellis</i> (<i>DV</i>) which exhibits various biological activities. However, its severe toxicity limits its use. In clinical settings, patients with <i>DV</i> poisoning often experience adverse reactions when taking large doses in a short period. The heart is an important toxic target organ, so it is necessary to conduct 24-h acute cardiac toxicity studies on PPT to understand its underlying toxicity mechanism.<h4>Methods</h4>Based on the concept of the toxicological evidence chain (TEC), we utilized targeted metabolomic and transcriptomic analyses to reveal the mechanism of the acute cardiotoxicity of PPT. The manifestation of toxi"],"journal":["Frontiers in pharmacology"],"pubmed_title":["Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept."],"pmcid":["PMC11463157"],"funding_grant_id":["82204938"],"pubmed_authors":["Sun L","Kui H","Huang S","Huang J","Jia C","Xie J","Que J","Ma K","Liu C","Zang S"],"additional_accession":[]},"is_claimable":false,"name":"Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept.","description":"<h4>Introduction</h4>Podophyllotoxin (PPT) is a high-content and high-activity compound extracted from the traditional Chinese medicinal plant <i>Dysosma versipellis</i> (<i>DV</i>) which exhibits various biological activities. However, its severe toxicity limits its use. In clinical settings, patients with <i>DV</i> poisoning often experience adverse reactions when taking large doses in a short period. The heart is an important toxic target organ, so it is necessary to conduct 24-h acute cardiac toxicity studies on PPT to understand its underlying toxicity mechanism.<h4>Methods</h4>Based on the concept of the toxicological evidence chain (TEC), we utilized targeted metabolomic and transcriptomic analyses to reveal the mechanism of the acute cardiotoxicity of PPT. The manifestation of toxi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-23T03:15:26.054Z","creation":"2025-04-04T01:51:57.299Z"},"accession":"S-EPMC11463157","cross_references":{"pubmed":["39386032"],"doi":["10.3389/fphar.2024.1378758"]}}