{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Unda SR"],"funding":["NINDS NIH HHS","NIH HHS"],"pagination":["eadp9150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11463271"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(41)"],"pubmed_abstract":["Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine-2a receptor-Cre drivers resulted in motor freezing when placed in a magnetic resonance imaging machine or adjacent to a transcranial magnetic stimulation device. Functional imaging and fiber photometry confirmed activation in response to magnetic fields. Expression of the same construct in the striatum of wild-type mice along with a second injection of an AAVretro expressing Cre into the globus pallidus led to similar circuit specificity and motor responses. Last, a mutation was generated to gate chloride and "],"journal":["Science advances"],"pubmed_title":["Bidirectional regulation of motor circuits using magnetogenetic gene therapy."],"pmcid":["PMC11463271"],"funding_grant_id":["OT2 OD024912","R01 NS097184"],"pubmed_authors":["Hassanzadeh G","Schaffer C","Vaisey G","Dyke JP","Nishimura N","Fung EK","Antoniazzi AM","Molina H","Grosenick L","Zirkel R","Wang P","Liston CM","Marongiu R","Kaplitt MG","Norman S","Kelly L","Pomeranz LE","Friedman JM","Unda SR","Yu X","Stanley SA"],"additional_accession":[]},"is_claimable":false,"name":"Bidirectional regulation of motor circuits using magnetogenetic gene therapy.","description":"Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine-2a receptor-Cre drivers resulted in motor freezing when placed in a magnetic resonance imaging machine or adjacent to a transcranial magnetic stimulation device. Functional imaging and fiber photometry confirmed activation in response to magnetic fields. Expression of the same construct in the striatum of wild-type mice along with a second injection of an AAVretro expressing Cre into the globus pallidus led to similar circuit specificity and motor responses. Last, a mutation was generated to gate chloride and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T08:18:10.817Z","creation":"2025-04-04T08:18:10.817Z"},"accession":"S-EPMC11463271","cross_references":{"pubmed":["39383230"],"doi":["10.1126/sciadv.adp9150"]}}