{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Krueger A"],"funding":["NIDDK NIH HHS","NIAID NIH HHS"],"pubmed_abstract":["Intracellular replication is crucial for the success of apicomplexan parasites, including <i>Toxoplasma gondii</i>. Therefore, essential players in parasite replication present potential targets for drug development. In this study, we have characterized TgGSK, a glycogen synthase kinase homolog that plays an important role in <i>Toxoplasma</i> endodyogeny. We have shown that TgGSK has a dynamic localization that is concurrent with the cell cycle. In non-dividing parasites, this kinase is highly concentrated in the nucleus. However, during division, TgGSK displays a cytosolic localization, with concentration foci at the centrosomes, a key organelle involved in parasite division, and the basal end. Conditional knockdown of TgGSK determined that it is essential for the completion of the lytic"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.09.27.615374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11463552"],"repository":["biostudies-literature"],"pubmed_title":["The essential kinase TgGSK regulates centrosome division and endodyogeny in &lt;i&gt;Toxoplasma gondii&lt;/i&gt;."],"pmcid":["PMC11463552"],"funding_grant_id":["R21 AI164619","R01 AI149766","R01 DK124067"],"pubmed_authors":["Arrizabalaga G","Francia ME","Blakely WJ","Horjales S","Yang C","Krueger A"],"additional_accession":[]},"is_claimable":false,"name":"The essential kinase TgGSK regulates centrosome division and endodyogeny in &lt;i&gt;Toxoplasma gondii&lt;/i&gt;.","description":"Intracellular replication is crucial for the success of apicomplexan parasites, including <i>Toxoplasma gondii</i>. Therefore, essential players in parasite replication present potential targets for drug development. In this study, we have characterized TgGSK, a glycogen synthase kinase homolog that plays an important role in <i>Toxoplasma</i> endodyogeny. We have shown that TgGSK has a dynamic localization that is concurrent with the cell cycle. In non-dividing parasites, this kinase is highly concentrated in the nucleus. However, during division, TgGSK displays a cytosolic localization, with concentration foci at the centrosomes, a key organelle involved in parasite division, and the basal end. Conditional knockdown of TgGSK determined that it is essential for the completion of the lytic","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T02:54:30.036Z","creation":"2025-04-04T02:54:30.036Z"},"accession":"S-EPMC11463552","cross_references":{"pubmed":["39386585"],"doi":["10.1101/2024.09.27.615374"]}}