biostudies-literatureDacomo LFondazione Cariploe14263https://www.ebi.ac.uk/biostudies/studies/S-EPMC11464142biostudies-literatureUnknown23(10)Frailty is a geriatric, multi-dimensional syndrome that reflects multisystem physiological change and is a transversal measure of reduced resilience to negative events. It is characterized by weakness, frequent falls, cognitive decline, increased hospitalization and dead and represents a risk factor for the development of Alzheimer's disease (AD). The fact that frailty is recognized as a reversible condition encourages the identification of earlier biomarkers to timely predict and prevent its occurrence. SAMP8 (Senescence-Accelerated Mouse Prone-8) mice represent the most appropriate preclinical model to this aim and were used in this study to carry transcriptional and metabolic analyses in the brain and plasma, respectively, upon a characterization at cognitive, motor, structural, and neuAging cellTranscriptomic and metabolomic changes might predict frailty in SAMP8 mice.PMC114641422017-05572017‐0557Leva SGagliardi SBrunelli LLa Vitola PArtioli LCecutti GCarelli SGuaita AForloni GMessa LPastorelli RMicotti ESinopoli EPansarasa ODacomo LBalducci CCereda CfalseTranscriptomic and metabolomic changes might predict frailty in SAMP8 mice.Frailty is a geriatric, multi-dimensional syndrome that reflects multisystem physiological change and is a transversal measure of reduced resilience to negative events. It is characterized by weakness, frequent falls, cognitive decline, increased hospitalization and dead and represents a risk factor for the development of Alzheimer's disease (AD). The fact that frailty is recognized as a reversible condition encourages the identification of earlier biomarkers to timely predict and prevent its occurrence. SAMP8 (Senescence-Accelerated Mouse Prone-8) mice represent the most appropriate preclinical model to this aim and were used in this study to carry transcriptional and metabolic analyses in the brain and plasma, respectively, upon a characterization at cognitive, motor, structural, and neu2024-01-01T00:00:00Z2024 Oct2026-07-14T20:34:34.766Z2025-04-06T16:25:25.911ZS-EPMC114641423896161310.1111/acel.14263