{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren L"],"funding":["Outstanding Young Talents Support Program in Colleges and Universities of Anhui Province","Innovation and Entrepreneurship Fund for the College Students","National Natural Science Foundation of China","Outstanding Youth Fund Project of Natural Science Foundation of Colleges and Universities in Anhui Province","Anhui Province University Innovation Team Project"],"pagination":["271"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11465571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Currently, the synthesis of compounds based on microbial cell factories is rapidly advancing, yet it encounters several challenges. During the production process, engineered strains frequently encounter disturbances in the cultivation environment or the impact of their metabolites, such as high temperature, acid-base imbalances, hypertonicity, organic solvents, toxic byproducts, and mechanical damage. These stress factors can constrain the efficiency of microbial fermentation, resulting in slow cell growth, decreased production, significantly increased energy consumption, and other issues that severely limit the application of microbial cell factories.<h4>Results</h4>This study demonstrated that sterol engineering in Kluyveromyces marxianus, achieved by overexpressing or"],"journal":["Microbial cell factories"],"pubmed_title":["Altered sterol composition mediates multiple tolerance of Kluyveromyces marxianus for xylitol production."],"pmcid":["PMC11465571"],"funding_grant_id":["2023AH010045","2023AH020039","22378156","gxyqZD2022043","202310373029"],"pubmed_authors":["Li J","Ren L","Xie Y","Hu Z","Tao X","Li F","Xu D","Zhang B","Zhang Q","Zha H"],"additional_accession":[]},"is_claimable":false,"name":"Altered sterol composition mediates multiple tolerance of Kluyveromyces marxianus for xylitol production.","description":"<h4>Background</h4>Currently, the synthesis of compounds based on microbial cell factories is rapidly advancing, yet it encounters several challenges. During the production process, engineered strains frequently encounter disturbances in the cultivation environment or the impact of their metabolites, such as high temperature, acid-base imbalances, hypertonicity, organic solvents, toxic byproducts, and mechanical damage. These stress factors can constrain the efficiency of microbial fermentation, resulting in slow cell growth, decreased production, significantly increased energy consumption, and other issues that severely limit the application of microbial cell factories.<h4>Results</h4>This study demonstrated that sterol engineering in Kluyveromyces marxianus, achieved by overexpressing or","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:16:58.14Z","creation":"2025-04-04T02:16:58.14Z"},"accession":"S-EPMC11465571","cross_references":{"pubmed":["39385269"],"doi":["10.1186/s12934-024-02546-3"]}}