{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Hong HX"],"pubmed_abstract":["<h4>Background</h4>Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP) caused infections of high mortality and brought a serious impact on public health. This study aims to evaluate the epidemiology, resistance and virulence characteristics of CR-hvKP and to identify potential drivers of cross-regional transmission in different regions of China, in order to provide a basis for developing targeted prevention measures.<h4>Methods</h4>Clinical K. pneumoniae strains were collected from Jiujiang and Nanchang in Jiangxi province between November 2021 to June 2022. Clinical data of patients (age, sex, source of infection, and diagnosis) were also gathered. We characterized these strains for their genetic relatedness using PFGE, antimicrobial and virulence plasmid structures usi"],"journal":["BMC microbiology"],"pagination":["400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11465609"],"repository":["biostudies-literature"],"pubmed_title":["Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China."],"pmcid":["PMC11465609"],"pubmed_authors":["Wei DD","Zhang W","Liu Y","Xiang TX","Huo BH","Huang QS","Hong HX","Liu P","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China.","description":"<h4>Background</h4>Carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKP) caused infections of high mortality and brought a serious impact on public health. This study aims to evaluate the epidemiology, resistance and virulence characteristics of CR-hvKP and to identify potential drivers of cross-regional transmission in different regions of China, in order to provide a basis for developing targeted prevention measures.<h4>Methods</h4>Clinical K. pneumoniae strains were collected from Jiujiang and Nanchang in Jiangxi province between November 2021 to June 2022. Clinical data of patients (age, sex, source of infection, and diagnosis) were also gathered. We characterized these strains for their genetic relatedness using PFGE, antimicrobial and virulence plasmid structures usi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-30T03:20:43.767Z","creation":"2025-04-06T23:04:40.487Z"},"accession":"S-EPMC11465609","cross_references":{"pubmed":["39385085"],"doi":["10.1186/s12866-024-03564-2"]}}