{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(11)"],"submitter":["Li Z"],"pubmed_abstract":["Glucose-like peptide-1 (GLP-1) is a vital hormone in the intestines that regulates glucose metabolism. Although pancreatic-derived factor (PANDER) overexpression is known to suppress GLP-1, the underlying mechanisms are unclear. Our study aims to uncover how PANDER influences GLP-1 synthesis and secretion. We established a PANDER overexpression model in STC-1 intestinal cells, confirming its inhibitory effect on GLP-1 secretion. This effect was reversed in PANDER-knockout cells. Additionally, a negative correlation between PANDER and GLP-1 was observed in patients with a history of gestational diabetes. Subsequently, through whole transcriptome gene sequencing in PANDER-overexpressed STC-1 cells, we discovered that the activation of IL-6 and its related STAT3 signaling pathway was signific"],"journal":["Endocrine connections"],"pagination":["e230548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11466252"],"repository":["biostudies-literature"],"pubmed_title":["The role of PANDER and its interplay with IL-6 in the regulation of GLP-1 secretion."],"pmcid":["PMC11466252"],"pubmed_authors":["Yue S","Chen N","Li Y","Li Z","Cao X","Pei L","Lai F","Xiao H","Xu C"],"additional_accession":[]},"is_claimable":false,"name":"The role of PANDER and its interplay with IL-6 in the regulation of GLP-1 secretion.","description":"Glucose-like peptide-1 (GLP-1) is a vital hormone in the intestines that regulates glucose metabolism. Although pancreatic-derived factor (PANDER) overexpression is known to suppress GLP-1, the underlying mechanisms are unclear. Our study aims to uncover how PANDER influences GLP-1 synthesis and secretion. We established a PANDER overexpression model in STC-1 intestinal cells, confirming its inhibitory effect on GLP-1 secretion. This effect was reversed in PANDER-knockout cells. Additionally, a negative correlation between PANDER and GLP-1 was observed in patients with a history of gestational diabetes. Subsequently, through whole transcriptome gene sequencing in PANDER-overexpressed STC-1 cells, we discovered that the activation of IL-6 and its related STAT3 signaling pathway was signific","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-07T07:41:40.967Z","creation":"2025-04-04T11:05:47.257Z"},"accession":"S-EPMC11466252","cross_references":{"pubmed":["39235859"],"doi":["10.1530/EC-23-0548"]}}