{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu C"],"funding":["NCI NIH HHS"],"pagination":["10933-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC114673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(22)"],"pubmed_abstract":["The potential roles of human herpesvirus 8 (HHV-8) cytokines in HHV-8 pathogenesis were investigated by determining the expression of the HHV-8 chemokines viral macrophage inflammatory protein 1A (vMIP-1A) and vMIP-1B in primary effusion lymphoma (PEL)-derived cell lines and examining the signaling activities of these chemokines and HHV-8-encoded vIL-6 in these cells. Secreted vMIP-1A and vMIP-1B were detected in biologically significant concentrations following tetradecanoyl phorbol acetate treatment, which induces productive replication. vIL-6 and vMIP-1A, added exogenously to cultures of four different PEL cell lines, induced the expression of vascular endothelial growth factor type B (VEGF-B) and VEGF-A, respectively. These cells were found to express VEGF receptor 1 (Flt-1) protein, a"],"journal":["Journal of virology"],"pubmed_title":["Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects."],"pmcid":["PMC114673"],"funding_grant_id":["R01 CA076445","CA76445"],"pubmed_authors":["Li H","Nicholas J","Liu C","Okruzhnov Y"],"additional_accession":[]},"is_claimable":false,"name":"Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects.","description":"The potential roles of human herpesvirus 8 (HHV-8) cytokines in HHV-8 pathogenesis were investigated by determining the expression of the HHV-8 chemokines viral macrophage inflammatory protein 1A (vMIP-1A) and vMIP-1B in primary effusion lymphoma (PEL)-derived cell lines and examining the signaling activities of these chemokines and HHV-8-encoded vIL-6 in these cells. Secreted vMIP-1A and vMIP-1B were detected in biologically significant concentrations following tetradecanoyl phorbol acetate treatment, which induces productive replication. vIL-6 and vMIP-1A, added exogenously to cultures of four different PEL cell lines, induced the expression of vascular endothelial growth factor type B (VEGF-B) and VEGF-A, respectively. These cells were found to express VEGF receptor 1 (Flt-1) protein, a","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Nov","modification":"2025-05-31T23:22:36.812Z","creation":"2019-03-27T00:17:05Z"},"accession":"S-EPMC114673","cross_references":{"pubmed":["11602733"],"doi":["10.1128/JVI.75.22.10933-10940.2001","10.1128/jvi.75.22.10933-10940.2001"]}}