{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bauer TA"],"funding":["Bundesministerium für Bildung und Forschung","Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg","Deutsche Forschungsgemeinschaft","Max-Planck-Gesellschaft"],"pagination":["e2100385"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(19)"],"pubmed_abstract":["Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(S-ethylsulfonyl-l-cysteine) block, yielding glutathione-responsive core cross-linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild-type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox-responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics."],"journal":["Advanced healthcare materials"],"pubmed_title":["Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages."],"pmcid":["PMC11468145"],"funding_grant_id":["SFB1036","Nr 031L0191C","SFB1118","DZL TLRC‐H","SFB1066"],"pubmed_authors":["Koynov K","Sotillo R","Hentze MW","Chocarro S","Carrella LM","Morsbach S","Schmitt S","Horvat NK","Colucci S","Mertens C","Barz M","Blumler P","Fenaroli F","Jung M","Muckenthaler MU","Bauer TA","Marques O"],"additional_accession":[]},"is_claimable":false,"name":"Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages.","description":"Iron is an essential co-factor for cellular processes. In the immune system, it can activate macrophages and represents a potential therapeutic for various diseases. To specifically deliver iron to macrophages, iron oxide nanoparticles are embedded in polymeric micelles of reactive polysarcosine-block-poly(S-ethylsulfonyl-l-cysteine). Upon surface functionalization via dihydrolipoic acid, iron oxide cores act as crosslinker themselves and undergo chemoselective disulfide bond formation with the surrounding poly(S-ethylsulfonyl-l-cysteine) block, yielding glutathione-responsive core cross-linked polymeric micelles (CCPMs). When applied to primary murine and human macrophages, these nanoparticles display preferential uptake, sustained intracellular iron release, and induce a strong inflammatory response. This response is also demonstrated in vivo when nanoparticles are intratracheally administered to wild-type C57Bl/6N mice. Most importantly, the controlled release concept to deliver iron oxide in redox-responsive CCPMs induces significantly stronger macrophage activation than any other iron source at identical iron levels (e.g., Feraheme), directing to a new class of immune therapeutics.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-18T14:09:32.937Z","creation":"2025-04-04T19:38:16.72Z"},"accession":"S-EPMC11468145","cross_references":{"pubmed":["34137217"],"doi":["10.1002/adhm.202100385"]}}