{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(1)"],"submitter":["Lv Y"],"pubmed_abstract":["<h4>Background</h4>Recent studies have highlighted the role of miR-5195-3p in suppressing cell growth in various cancers. However, the specific functional impact of miR-5195-3p in colorectal cancer (CRC) remain to be fully clarified. The importance of miR-5195-3p in CRC was evaluated, aiming to uncover its underlying molecular mechanism and identify it as a potential therapeutic target for CRC.<h4>Results</h4>Our research has shown that miR-5195-3p is markedly under-expressed in CRC tissues and cell cultures, with its reduced presence associated with a higher TNM stage, lymphatic invasion, and unfavorable survival outcome. Ectopic miR-5195-3p expression curtailed proliferation, migration, and invasion of SW1116 and HT29 cells. Additionally, we discovered that miR-5195-3p directly targets a"],"journal":["Cell division"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468180"],"repository":["biostudies-literature"],"pubmed_title":["MiR-5195-3p predicts clinical prognosis and represses colorectal cancer progression by targeting TLR4/MyD88 signaling."],"pmcid":["PMC11468180"],"pubmed_authors":["Liu H","Li H","Li Y","Lu Y","Lv Y","Guo S","Wang K","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"MiR-5195-3p predicts clinical prognosis and represses colorectal cancer progression by targeting TLR4/MyD88 signaling.","description":"<h4>Background</h4>Recent studies have highlighted the role of miR-5195-3p in suppressing cell growth in various cancers. However, the specific functional impact of miR-5195-3p in colorectal cancer (CRC) remain to be fully clarified. The importance of miR-5195-3p in CRC was evaluated, aiming to uncover its underlying molecular mechanism and identify it as a potential therapeutic target for CRC.<h4>Results</h4>Our research has shown that miR-5195-3p is markedly under-expressed in CRC tissues and cell cultures, with its reduced presence associated with a higher TNM stage, lymphatic invasion, and unfavorable survival outcome. Ectopic miR-5195-3p expression curtailed proliferation, migration, and invasion of SW1116 and HT29 cells. Additionally, we discovered that miR-5195-3p directly targets a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T13:54:48.029Z","creation":"2025-04-04T13:54:48.029Z"},"accession":"S-EPMC11468180","cross_references":{"pubmed":["39390599"],"doi":["10.1186/s13008-024-00133-x"]}}