{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["75(22)"],"submitter":["Yeh CT"],"pubmed_abstract":["Although hepatitis C virus E2 protein can bind to human cells by interacting with a putative viral receptor, CD81, the interaction alone is not sufficient to establish permissiveness for hepatitis C virus infection. Using an Epstein-Barr virus-based extrachromosomal replication system, we have screened through a human liver cDNA library and successfully identified a cDNA capable of supporting hepatitis C virus replication in an otherwise nonpermissive cell line. This cDNA encodes a protein exhibiting homology to a group of proteins derived from various evolutionarily distant species, including Oryza sativa submergence-induced protein 2A. The mRNAs encoding this factor are heterogeneous at the 5' ends and are ubiquitously expressed in multiple tissues, albeit in a very small amount. The lon"],"journal":["Journal of virology"],"pagination":["11017-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC114682"],"repository":["biostudies-literature"],"pubmed_title":["Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line."],"pmcid":["PMC114682"],"pubmed_authors":["Chu CM","Liaw YF","Lai HY","Chen TC","Yeh CT"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line.","description":"Although hepatitis C virus E2 protein can bind to human cells by interacting with a putative viral receptor, CD81, the interaction alone is not sufficient to establish permissiveness for hepatitis C virus infection. Using an Epstein-Barr virus-based extrachromosomal replication system, we have screened through a human liver cDNA library and successfully identified a cDNA capable of supporting hepatitis C virus replication in an otherwise nonpermissive cell line. This cDNA encodes a protein exhibiting homology to a group of proteins derived from various evolutionarily distant species, including Oryza sativa submergence-induced protein 2A. The mRNAs encoding this factor are heterogeneous at the 5' ends and are ubiquitously expressed in multiple tissues, albeit in a very small amount. The lon","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Nov","modification":"2025-05-31T23:22:37.333Z","creation":"2019-03-27T00:17:05Z"},"accession":"S-EPMC114682","cross_references":{"pubmed":["11602742"],"doi":["10.1128/jvi.75.22.11017-11024.2001","10.1128/JVI.75.22.11017-11024.2001"]}}