{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luken A"],"funding":["Deutsche Forschungsgemeinschaft","Horizon 2020 Framework Programme"],"pagination":["e2100898"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(20)"],"pubmed_abstract":["For successful material deployment in tissue engineering, the material itself, its mechanical properties, and the microscopic geometry of the product are of particular interest. While silk is a widely applied protein-based tissue engineering material with strong mechanical properties, the size and shape of artificially spun silk fibers are limited by existing processes. This study adjusts a microfluidic spinneret to manufacture micron-sized wet-spun fibers with three different materials enabling diverse geometries for tissue engineering applications. The spinneret is direct laser written (DLW) inside a microfluidic polydimethylsiloxane (PDMS) chip using two-photon lithography, applying a novel surface treatment that enables a tight print-channel sealing. Alginate, polyacrylonitrile, and si"],"journal":["Advanced healthcare materials"],"pubmed_title":["Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning."],"pmcid":["PMC11468244"],"funding_grant_id":["WE 4678/12‐1","“BioComb4Nanofibers” 862016","436799631"],"pubmed_authors":["Joel AC","Linkhorst J","Geiger M","Lampert A","Steinbeck L","Wessling M","Luken A"],"additional_accession":[]},"is_claimable":false,"name":"Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning.","description":"For successful material deployment in tissue engineering, the material itself, its mechanical properties, and the microscopic geometry of the product are of particular interest. While silk is a widely applied protein-based tissue engineering material with strong mechanical properties, the size and shape of artificially spun silk fibers are limited by existing processes. This study adjusts a microfluidic spinneret to manufacture micron-sized wet-spun fibers with three different materials enabling diverse geometries for tissue engineering applications. The spinneret is direct laser written (DLW) inside a microfluidic polydimethylsiloxane (PDMS) chip using two-photon lithography, applying a novel surface treatment that enables a tight print-channel sealing. Alginate, polyacrylonitrile, and si","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-08T06:24:16.134Z","creation":"2025-04-04T02:17:04.548Z"},"accession":"S-EPMC11468244","cross_references":{"pubmed":["34331524"],"doi":["10.1002/adhm.202100898"]}}