{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klubthawee N"],"funding":["Swiss National Science Foundation"],"pagination":["e2101426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468357"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(7)"],"pubmed_abstract":["Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemic"],"journal":["Advanced healthcare materials"],"pubmed_title":["Biopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery."],"pmcid":["PMC11468357"],"funding_grant_id":["200021_184697"],"pubmed_authors":["Marco-Dufort B","Guzzi EA","Tibbitt MW","Bovone G","Aunpad R","Klubthawee N"],"additional_accession":[]},"is_claimable":false,"name":"Biopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery.","description":"Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemic","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T13:54:40.997Z","creation":"2025-04-04T13:54:40.997Z"},"accession":"S-EPMC11468357","cross_references":{"pubmed":["34936732"],"doi":["10.1002/adhm.202101426"]}}