biostudies-literatureKlubthawee NSwiss National Science Foundatione2101426https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468357biostudies-literatureUnknown11(7)Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemicAdvanced healthcare materialsBiopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery.PMC11468357200021_184697Marco-Dufort BGuzzi EATibbitt MWBovone GAunpad RKlubthawee NfalseBiopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery.Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemic2022-01-01T00:00:00Z2022 Apr2025-04-04T13:54:40.997Z2025-04-04T13:54:40.997ZS-EPMC114683573493673210.1002/adhm.202101426