{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Costa JNY"],"funding":["São Paulo Research Foundation","Brazilian National Council for Scientific and Technological Development","Brazilian Coordination for Improvement of Higher Education Personnel","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["e2303509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy. Exploiting the vertical, meshed design of reproducible and low-cost ultra-dense electrochemical chips, the unprecedented single-response multiplexing of typical label-free biosensors is reported. Using a cheap, handheld one-channel workstation and a single redox probe, that is, ferro/ferricyanide, the recognition events taking place on two spatially resolved locations of the same working electrode can be tracked along a single voltammetry scan by collecting the electrochemical signatures of the probe in relation to different quasi-reference electrodes, Au (0 V) and Ag/AgCl ink (+0.2 V). This spatial isolation prevents crosstalk between the redox tags and interferences over functionalization and binding s"],"journal":["Advanced healthcare materials"],"pubmed_title":["Single-Response Duplexing of Electrochemical Label-Free Biosensor from the Same Tag."],"pmcid":["PMC11468374"],"funding_grant_id":["2022/04397-1","88887.663312/2022-00","407951/2021-0","2022/04397‐1","2023/02080‐3","304389/2019-6","2023/02080-3"],"pubmed_authors":["Lima RS","Ayres LB","Shimizu FM","Santhiago M","Paschoalino WJ","Garcia CD","Piazzetta MHO","Vieira LCS","Poker JA","Kubota LT","Castro ACH","Merces L","Costa JNY","Pimentel GJC","Alves WA","Gobbi AL"],"additional_accession":[]},"is_claimable":false,"name":"Single-Response Duplexing of Electrochemical Label-Free Biosensor from the Same Tag.","description":"Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy. Exploiting the vertical, meshed design of reproducible and low-cost ultra-dense electrochemical chips, the unprecedented single-response multiplexing of typical label-free biosensors is reported. Using a cheap, handheld one-channel workstation and a single redox probe, that is, ferro/ferricyanide, the recognition events taking place on two spatially resolved locations of the same working electrode can be tracked along a single voltammetry scan by collecting the electrochemical signatures of the probe in relation to different quasi-reference electrodes, Au (0 V) and Ag/AgCl ink (+0.2 V). This spatial isolation prevents crosstalk between the redox tags and interferences over functionalization and binding s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-07T07:35:54.148Z","creation":"2025-04-04T13:53:53.121Z"},"accession":"S-EPMC11468374","cross_references":{"pubmed":["38245830"],"doi":["10.1002/adhm.202303509"]}}