biostudies-literatureUnknown25(1)Miyake A<h4>Background</h4>Hypertensive emergency is a critical disease that causes multiple organ injuries. Although the renin-angiotensin-aldosterone system (RAS) is enormously activated in this disorder, whether the RAS contributes to the development of the organ damage has not been fully elucidated. This cross-sectional study was conducted to characterize the association between RAS and the organ damage in patients with hypertensive emergencies.<h4>Methods</h4>We enrolled 63 patients who visited our medical center with acute severe hypertension and multiple organ damage between 2012 and 2020. Hypertensive target organ damage was evaluated on admission, including severe kidney impairment (eGFR less than 30 mL/min/1.73 m², SKI), severe retinopathy, concentric left ventricular hypertroBMC nephrology342https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468402biostudies-literatureRole of aldosterone in various target organ damage in patients with hypertensive emergency: a cross-sectional study.PMC11468402Suzuki TEndo KImai NYoshino KHara YFujitani SHirai TIto SKitamura KSakai MTakano KHayashi KMiyake AHorikawa TfalseRole of aldosterone in various target organ damage in patients with hypertensive emergency: a cross-sectional study.<h4>Background</h4>Hypertensive emergency is a critical disease that causes multiple organ injuries. Although the renin-angiotensin-aldosterone system (RAS) is enormously activated in this disorder, whether the RAS contributes to the development of the organ damage has not been fully elucidated. This cross-sectional study was conducted to characterize the association between RAS and the organ damage in patients with hypertensive emergencies.<h4>Methods</h4>We enrolled 63 patients who visited our medical center with acute severe hypertension and multiple organ damage between 2012 and 2020. Hypertensive target organ damage was evaluated on admission, including severe kidney impairment (eGFR less than 30 mL/min/1.73 m², SKI), severe retinopathy, concentric left ventricular hypertro2024-01-01T00:00:00Z2024 Oct2026-06-13T05:42:56.973Z2025-04-04T01:17:22.116ZS-EPMC114684023939038210.1186/s12882-024-03769-7