{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Z"],"funding":["Natural Science Foundation of Shandong Province","National Natural Science Foundation of China","Taishan scholar program of Shandong Province"],"pagination":["273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468453"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Ficolins (FCNs) are a family of proteins, comprising FCN1, FCN2 and FCN3, and integral to the immune system which have been implicated in the onset and progression of tumors. Despite their recognized roles, a comprehensive analysis of FCNs in lung cancer remains elusive.<h4>Methods</h4>We employed a variety of bioinformatics tools, including UCSC, SangerBox, Ualcan, cBioPortal, String, Metascape, GeneMANIA, TIDE, CTD, and CAMP databases to investigate the differential expression, diagnostic and prognostic significance, genetic alterations, functional enrichment, immune infiltration, and potential immunotherapeutic implications of FCN1, FCN2, and FCN3 in lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Additionally, RT-qPCR and immunohistochemistry were"],"journal":["World journal of surgical oncology"],"pubmed_title":["Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer."],"pmcid":["PMC11468453"],"funding_grant_id":["82172347","ZR2020MH323","tstp20221156"],"pubmed_authors":["Liu Y","Hu D","Zhang Z","Geng X","Yin M","Zhang S","Zheng G"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer.","description":"<h4>Background</h4>Ficolins (FCNs) are a family of proteins, comprising FCN1, FCN2 and FCN3, and integral to the immune system which have been implicated in the onset and progression of tumors. Despite their recognized roles, a comprehensive analysis of FCNs in lung cancer remains elusive.<h4>Methods</h4>We employed a variety of bioinformatics tools, including UCSC, SangerBox, Ualcan, cBioPortal, String, Metascape, GeneMANIA, TIDE, CTD, and CAMP databases to investigate the differential expression, diagnostic and prognostic significance, genetic alterations, functional enrichment, immune infiltration, and potential immunotherapeutic implications of FCN1, FCN2, and FCN3 in lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Additionally, RT-qPCR and immunohistochemistry were","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T13:54:47.122Z","creation":"2025-04-04T13:54:47.122Z"},"accession":"S-EPMC11468453","cross_references":{"pubmed":["39390580"],"doi":["10.1186/s12957-024-03558-4"]}}