biostudies-literatureUnknown33(42)Ruland APrecision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplAdvanced materials (Deerfield Beach, Fla.)e2102489https://www.ebi.ac.uk/biostudies/studies/S-EPMC11468472biostudies-literatureAmphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization.PMC11468472Ruland ASchirmer LValtin JHelmecke THahn DFreudenberg UMacDonald WRenner LDFriedrichs JSchwartz VBSchenker SMeinhardt ASikosana MKLNKonradi RWerner CKaiser NfalseAmphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization.Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodispl2021-01-01T00:00:00Z2021 Oct2025-04-05T23:44:43.693Z2025-04-05T23:44:43.693ZS-EPMC114684723443156910.1002/adma.202102489